Structure of PDB 4fdc Chain B

Receptor sequence
>4fdcB (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]
APSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSK
ELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAV
LTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEV
KSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALG
TEVIQLFPEKGNMGKILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSG
KLLIKLKDGRKVETDHIVAAVGLEPNVELAKTGGLEIDSDFGGFRVNAEL
QARSNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPYW
HQSMFWSDLGPDVGYVAIGLVDSSLPTVGVFAKATAQDNPKSATEQSGTG
IRSESETESEYGKGVIFYLRDKVVVGIVLWNIFNRMPIARKIIKDGEQHE
DLNEVAKLFNI
3D structure
PDB4fdc Cowchock syndrome is associated with a mutation in apoptosis-inducing factor.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.6.99.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G138 G139 G140 T141 A142 E164 R172 P173 K177 K232 V233 T260 G261 F284 R285 G437 D438 E453 H454 H455 F482 W483 G11 G12 G13 T14 A15 E37 R45 P46 K50 K105 V106 T133 G134 F157 R158 G310 D311 E326 H327 H328 F355 W356
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0046983 protein dimerization activity

View graph for
Molecular Function
External links
PDB RCSB:4fdc, PDBe:4fdc, PDBj:4fdc
PDBsum4fdc
PubMed23217327
UniProtO95831|AIFM1_HUMAN Apoptosis-inducing factor 1, mitochondrial (Gene Name=AIFM1)

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