Structure of PDB 4fcx Chain B

Receptor sequence
>4fcxB (length=369) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
SENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLG
GDIFHDNKPSRKALYQALRSLRLNCLGDKPCELELLSVCNINYLDPNINV
AIPVFSIHGNHDRYSALDILQVTGLVNYFGRVPENDNIVVSPILLQKGFT
KLALYGISNVRDERLYHSFRENKVKFLRPDLYRDEWFNLLTVHQNHSAHT
PTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQPGSTIATSL
SPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSVENKKE
VLTYLISKVEEAITEANAQWYEAQEKPPLPLIRLRVDYTGGYQTENPQRF
SNRFVGRVANATDVVQFYL
3D structure
PDB4fcx Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
ChainB
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN B D25 H27 D65 H252 D12 H14 D52 H223
BS02 MN B D65 N133 H222 H250 D52 N110 H193 H221
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0008296 3'-5'-DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
Biological Process
GO:0006302 double-strand break repair
Cellular Component
GO:0005634 nucleus
GO:0030870 Mre11 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fcx, PDBe:4fcx, PDBj:4fcx
PDBsum4fcx
PubMed22705791
UniProtQ09683|RAD32_SCHPO Double-strand break repair protein rad32 (Gene Name=rad32)

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