Structure of PDB 4f9v Chain B

Receptor sequence
>4f9vB (length=299) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
QWRDDEVHFNRTLDSILVPRVVGSRGHQQVREYLVQSLNGLGFQTEVDEF
KQRVPVFGELTFANVVGTINPQAQNFLALAAHYDSKYFPNDPGFVGATDS
AVPAAILLNTAKTLGAYLQKEFRNRSDVGLMLIFFDGEEAFKEWTDADSV
YGSKHLAAKLASKRAPRNIDRIEVLVLLDLIGARNPKFSSFYENTDGLHS
SLVQIEKSLRTAGQLEGNNNMFLSRVSGGLVDDDHRPFLDENVPVLHLVA
TPFPDVWHTPRDNAANLHWPSIRNFNRVFRNFVYQYLKRHTSPVNLRFY
3D structure
PDB4f9v Crystal Structures of Glutaminyl Cyclases (QCs) from Drosophila melanogaster Reveal Active Site Conservation between Insect and Mammalian QCs.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D131 E171 H297 D99 E139 H258
BS02 PBD B D131 E170 E171 W176 D218 D271 F292 H297 D99 E138 E139 W144 D179 D232 F253 H258
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4f9v, PDBe:4f9v, PDBj:4f9v
PDBsum4f9v
PubMed22897232
UniProtQ9VRQ9|QPCT1_DROME Glutaminyl-peptide cyclotransferase (Gene Name=QC)

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