Structure of PDB 4f8h Chain B

Receptor sequence
>4f8hB (length=311) Species: 251221 (Gloeobacter violaceus PCC 7421) [Search protein sequence]
VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAF
DPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLE
RFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDD
VFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP
MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAFNILVETNLPKTPYMTY
TGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFL
LANIILAFLFF
3D structure
PDB4f8h Structure of the Pentameric Ligand-Gated Ion Channel GLIC Bound with Anesthetic Ketamine.
ChainB
Resolution2.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RKE B F174 L176 K183 F170 L172 K179 PDBbind-CN: -logKd/Ki=4.24,IC50=58uM
BS02 RKE B Y23 N152 D153 D154 Y19 N148 D149 D150 PDBbind-CN: -logKd/Ki=4.24,IC50=58uM
BS03 LMD B D31 I233 A237 N245 D27 I229 A233 N241
BS04 LMD B A234 A237 A230 A233
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:4f8h, PDBe:4f8h, PDBj:4f8h
PDBsum4f8h
PubMed22958642
UniProtQ7NDN8|GLIC_GLOVI Proton-gated ion channel (Gene Name=glvI)

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