Structure of PDB 4f4u Chain B

Receptor sequence
>4f4uB (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
FTARPSSSMADFRKFFAKAKHIVIISGAGVSAGYWRKWQAQDLATPLAFA
HNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNI
DELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEP
GTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC
DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGP
CGTTLPEALA
3D structure
PDB4f4u The Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N141 D143 H158
Catalytic site (residue number reindexed from 1) N99 D101 H116
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q83 Y102 R105 I142 H158 V221 W222 F223 G224 E225 N226 L227 V253 V254 Y255 Q41 Y60 R63 I100 H116 V179 W180 F181 G182 E183 N184 L185 V211 V212 Y213
BS02 ZN B C166 C169 C207 C212 C124 C127 C165 C170
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4f4u, PDBe:4f4u, PDBj:4f4u
PDBsum4f4u
PubMed22767592
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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