Structure of PDB 4f2b Chain B

Receptor sequence
>4f2bB (length=302) Species: 426430 (Staphylococcus aureus subsp. aureus str. Newman) [Search protein sequence]
DSLSKSPENWMSKLDDGKHLTEINIPGSHDSGSFTLKDPVKSVWAKTQDK
DYLTQMKSGVRFFDIRGRASADNMISVHHGMVYLHHELGKFLDDAKYYLS
AYPNETIVMSMKKDYDSDSKVTKTFEEIFREYYYNNPQYQNLFYTGSNAN
PTLKETKGKIVLFNRMGGTYIKSGYGADTSGIQWADNATFETKINNGSLN
LKVQDEYKDYYDKKVEAVKNLLAKAKTDSNKDNVYVNFLSVASGGSAFNS
TYNYASHINPEIAKTIKANGKARTGWLIVDYAGYTWPGYDDIVSEIIDSN
KL
3D structure
PDB4f2b Competition between Anion Binding and Dimerization Modulates Staphylococcus aureus Phosphatidylinositol-specific Phospholipase C Enzymatic Activity.
ChainB
Resolution2.16 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H30 D31 R67 H80 D281
Catalytic site (residue number reindexed from 1) H29 D30 R66 H79 D280
Enzyme Commision number 4.6.1.13: phosphatidylinositol diacylglycerol-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 INS B H30 R67 K113 D206 H29 R66 K112 D205
Gene Ontology
Molecular Function
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4f2b, PDBe:4f2b, PDBj:4f2b
PDBsum4f2b
PubMed23038258
UniProtP45723|PLC_STAAE 1-phosphatidylinositol phosphodiesterase (Gene Name=plc)

[Back to BioLiP]