Structure of PDB 4f1l Chain B

Receptor sequence
>4f1lB (length=181) Species: 9606 (Homo sapiens) [Search protein sequence]
KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQA
KKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYGKGTYFAVNAN
YSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLY
DTVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB4f1l Discovery of Ligands for ADP-Ribosyltransferases via Docking-Based Virtual Screening.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RY B H1601 G1602 Y1633 F1634 A1635 S1641 Y1646 H70 G71 Y94 F95 A96 S102 Y107 BindingDB: IC50=>20000nM,Kd=7600nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4f1l, PDBe:4f1l, PDBj:4f1l
PDBsum4f1l
PubMed22823910
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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