Structure of PDB 4ezh Chain B

Receptor sequence
>4ezhB (length=451) Species: 10090 (Mus musculus) [Search protein sequence]
ESYLSPAQSVKPKIEKLPREKLNPPTPSIYLESKRDAFSPVLLQFCTDPR
NPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVEVRTQVQQPSDENWDL
TGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQEELEVLFHHIIKFGTN
IDLSDAKRWKPQLQELLKLPAFMRVTSTGNMLSHVGHTILGMNTVQLYMK
VPGSRTPGHQENNNFCSVNINIGPGDCEWFAVHEHYWETISAFCDRHGVD
YLTGSWWPILDDLYASNIPVYRFVQRPGDLVWINAGTVHWVQATGWCNNI
AWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPD
LFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVE
VFNILFVTSTYLVHCEGCARRRSAGLQGVVVLEQYRTEELAQAYDAFTLA
P
3D structure
PDB4ezh A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
ChainB
Resolution2.52 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B E1244 R1246 E1269 S1270 R1272 N1331 D1333 I1370 L1371 G1372 Q1377 G1435 A1482 W1483 N1484 E85 R87 E110 S111 R113 N150 D152 I189 L190 G191 Q196 G254 A301 W302 N303
BS02 ZN B C1575 C1578 C1602 C1605 C394 C397 C415 C418
External links
PDB RCSB:4ezh, PDBe:4ezh, PDBj:4ezh
PDBsum4ezh
PubMed22842901
UniProtQ5NCY0|KDM6B_MOUSE Lysine-specific demethylase 6B (Gene Name=Kdm6b)

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