Structure of PDB 4eyl Chain B

Receptor sequence
>4eylB (length=240) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
PTIGQQMETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRD
GGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDAL
HAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKV
FYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAAS
ARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLRLV
3D structure
PDB4eyl New Delhi Metallo-Beta-Lactamase: Structural Insights into Beta-Lactam Recognition and Inhibition
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H120 H122 D124 H189 C208 K211 N220 H250
Catalytic site (residue number reindexed from 1) H88 H90 D92 H157 C176 K179 N188 H218
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RV B H122 D124 H189 C208 K211 S217 G219 N220 H250 H90 D92 H157 C176 K179 S185 G187 N188 H218
BS02 ZN B D124 C208 H250 D92 C176 H218
BS03 ZN B H120 H122 H189 H88 H90 H157
External links
PDB RCSB:4eyl, PDBe:4eyl, PDBj:4eyl
PDBsum4eyl
PubMed22713171
UniProtC7C422|BLAN1_KLEPN Metallo-beta-lactamase type 2 (Gene Name=blaNDM-1)

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