Structure of PDB 4ere Chain B

Receptor sequence
>4ereB (length=90) Species: 9606 (Homo sapiens) [Search protein sequence]
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB4ere Structure-based design of novel inhibitors of the MDM2-p53 interaction.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0R2 B K51 L54 I61 V93 K94 H96 Y100 K35 L38 I45 V72 K73 H75 Y79 MOAD: ic50=4.2nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4ere, PDBe:4ere, PDBj:4ere
PDBsum4ere
PubMed22524527
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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