Structure of PDB 4epp Chain B

Receptor sequence
>4eppB (length=439) Species: 5911 (Tetrahymena thermophila) [Search protein sequence]
DYQFPLPQKNSELWIIQKKTLQDLSSGKQKLDSFQSLESILEILRDSKNQ
NDEKYFNLKAVFEQLDKEEQTYFLEQFIPKICQLVLKIKKKQLKNQIPKE
SKIYEAAFSREEISYYVSCMFLCILKDQDRKIYKDFRLIYLKDLVQQINI
RRQEKIKCFYEYLKQALDFSEKESKEVVIFQRINCGQLEDYENWVDKLKA
IKLKNVQLTDDKLIEDFPGTLQVDFANCDIGGGILGNGLVQEEIRFCVCP
EMLVSLLVFDQSMEANEVIIMKGIKQYSDYQGYSNSFRFVKMGNSKIQKQ
KRNNPQTILAIDALCFNSSDNQFSEVNVSRELNKSYMGFKQEDQLKTIST
GKWGCGAFLGVFDLKFAIQWIASSRSNKKMIICTFQDEQTTKQIQQVFDL
YKQKNASIFLKLVMDYPNSKYMEDYTLLEYLIELGKEKA
3D structure
PDB4epp Structure and mechanism of a canonical poly(ADP-ribose) glycohydrolase.
ChainB
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR B L226 I227 F238 N240 V253 Q254 E255 E256 Y296 K365 G367 G369 A370 F371 F398 L213 I214 F225 N227 V240 Q241 E242 E243 Y283 K352 G354 G356 A357 F358 F385
Gene Ontology
Molecular Function
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0016787 hydrolase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006282 regulation of DNA repair
GO:0009225 nucleotide-sugar metabolic process
GO:1990966 ATP generation from poly-ADP-D-ribose
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4epp, PDBe:4epp, PDBj:4epp
PDBsum4epp
PubMed22673905
UniProtI6L8L8

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