Structure of PDB 4ene Chain B

Receptor sequence
>4eneB (length=442) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
RRRQLIRQLLERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMG
ALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPEAGGSGIPEIEGAL
EDQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGPTVQIGGNIGRMVLDIF
RLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRPQFRYTLISIK
AVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIFG
PIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLGFVAPATSGGG
FNLIPIATAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTV
LGTAFGMVAVELFPQYHLEAGTFAIAGMGALLAASIRAPLTGIILVLEMT
DNYQLILPMIITGLGATLLAQFTGGKPLYSAILARTLAKQEA
3D structure
PDB4ene Intracellular proton access in a cl(-)/h(+) antiporter.
ChainB
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC B R28 I213 S214 R12 I197 S198
BS02 GLC B E27 E172 E11 E156
BS03 GLC B W125 D164 W109 D148
BS04 GLC B W124 D164 R167 W108 D148 R151
BS05 CL B S107 G355 F357 Y445 S91 G339 F341 Y429
BS06 CL B S107 P110 S91 P94
Gene Ontology
Molecular Function
GO:0005247 voltage-gated chloride channel activity
GO:0015297 antiporter activity
GO:0042802 identical protein binding
GO:0062158 chloride:proton antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006821 chloride transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:1902600 proton transmembrane transport
GO:1990451 cellular stress response to acidic pH
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ene, PDBe:4ene, PDBj:4ene
PDBsum4ene
PubMed23239938
UniProtP37019|CLCA_ECOLI H(+)/Cl(-) exchange transporter ClcA (Gene Name=clcA)

[Back to BioLiP]