Structure of PDB 4em6 Chain B

Receptor sequence
>4em6B (length=546) Species: 224914 (Brucella melitensis bv. 1 str. 16M) [Search protein sequence]
RDATKLEATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDW
SKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRD
TSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNI
GIGGSDLGPVMATLALAPYHDEPRAHFVSNIDGAHIADTLSPLDPASTLI
IVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFG
IPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHF
RDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDM
ESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFI
VAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQ
VERIAPHRVFSGNRPSLTLIHDMLDPYTLGRLIALYEHRVFVEAQIFGIN
AFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRK
3D structure
PDB4em6 The structure of Glucose-6-phosphate isomerase (GPI) from Brucella melitensis
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K207 E213 G267 R268 E353 H384 K513
Catalytic site (residue number reindexed from 1) K205 E211 G265 R266 E351 H382 K511
Enzyme Commision number 5.3.1.9: glucose-6-phosphate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B A169 H172 A167 H170
Gene Ontology
Molecular Function
GO:0004347 glucose-6-phosphate isomerase activity
GO:0016853 isomerase activity
GO:0048029 monosaccharide binding
GO:0097367 carbohydrate derivative binding
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0051156 glucose 6-phosphate metabolic process
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4em6, PDBe:4em6, PDBj:4em6
PDBsum4em6
PubMed
UniProtQ8YF86|G6PI_BRUME Glucose-6-phosphate isomerase (Gene Name=pgi)

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