Structure of PDB 4ekq Chain B

Receptor sequence
>4ekqB (length=174) Species: 10665 (Tequatrovirus T4) [Search protein sequence]
TTENLYFQGSMNIFEMLRIDEGLRLKIYKDCEGYYTIGIGHLLTKSPDLN
AAKSELDKAIGRNCNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDS
LDAVRRCAAINHVFQMGVTGVAGFTNVLRMLQQKRWDEAAVNLAKSRWYN
QCPDRAKRVITTFRTGTWDAYKNL
3D structure
PDB4ekq Engineering a model protein cavity to catalyze the Kemp elimination.
ChainB
Resolution1.54 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E11 D20
Catalytic site (residue number reindexed from 1) E21 D30
Enzyme Commision number 3.2.1.17: lysozyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NPO B I78 V87 Y88 A99 H102 V111 L118 L121 F153 I88 V97 Y98 A109 H112 V121 L128 L131 F163 MOAD: Kd=2uM
BindingDB: Kd=3000nM
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0009253 peptidoglycan catabolic process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044659 viral release from host cell by cytolysis
Cellular Component
GO:0030430 host cell cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ekq, PDBe:4ekq, PDBj:4ekq
PDBsum4ekq
PubMed22988064
UniProtP00720|ENLYS_BPT4 Endolysin (Gene Name=E)

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