Structure of PDB 4ed5 Chain B

Receptor sequence
>4ed5B (length=169) Species: 9606 (Homo sapiens) [Search protein sequence]
GRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVN
YVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYISGLPRTM
TQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSF
NGHKPPGSSEPITVKFAAN
3D structure
PDB4ed5 The structure of the ARE-binding domains of Hu antigen R (HuR) undergoes conformational changes during RNA binding.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna B I23 N25 Y26 K50 I52 S60 L61 Y63 F65 K89 T90 K92 A96 R97 S99 I103 K104 Y109 I133 R136 R147 F151 R153 A185 I6 N8 Y9 K33 I35 S43 L44 Y46 F48 K72 T73 K75 A79 R80 S82 I86 K87 Y92 I116 R119 R130 F134 R136 A168 PDBbind-CN: Kd=169nM
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Cellular Component
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:4ed5, PDBe:4ed5, PDBj:4ed5
PDBsum4ed5
PubMed23519412
UniProtQ15717|ELAV1_HUMAN ELAV-like protein 1 (Gene Name=ELAVL1)

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