Structure of PDB 4ech Chain B

Receptor sequence
>4echB (length=483) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRK
YDIGASWHQDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVD
HDKELLLEIVDNEMSKFAELEFDCSFFQLVMKYLLQRRQFLTNDQIRYLP
QLCRYLELWHGLDWKLLSAKDTYFGHQGRNAFALNYDSVVQRIAQSFPQN
WLKLSCEVKSITREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPE
KNLRGRIEFQPPLKPVIQDAFDKIHFGALGKVIFEFEECCWSNESSKIVT
LANSTNEFVEIVRNAENLDELDSMLERSVTCWSQPLFFVNLSKSTGVASF
MMLMQAPLTNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVIDGMRPIA
NKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPVDMVVAMSNGQDSRIRFA
GEHTIMDGAGCAYGAWESGRREATRISDLLKLE
3D structure
PDB4ech Mechanistic and structural analyses of the role of his67 in the yeast polyamine oxidase fms1.
ChainB
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q67
Catalytic site (residue number reindexed from 1) Q59
Enzyme Commision number 1.5.3.17: non-specific polyamine oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G15 G17 A19 E39 A40 G46 R47 G62 A63 W65 Q67 V223 V253 L294 A449 Y450 G478 E479 G487 C488 A489 A492 G7 G9 A11 E31 A32 G38 R39 G54 A55 W57 Q59 V208 V238 L279 A422 Y423 G451 E452 G460 C461 A462 A465
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046592 polyamine oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0052897 N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
GO:0052901 spermine oxidase activity
GO:0052903 N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity
Biological Process
GO:0006338 chromatin remodeling
GO:0015940 pantothenate biosynthetic process
GO:0046208 spermine catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ech, PDBe:4ech, PDBj:4ech
PDBsum4ech
PubMed22642831
UniProtP50264|FMS1_YEAST Polyamine oxidase FMS1 (Gene Name=FMS1)

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