Structure of PDB 4eb7 Chain B

Receptor sequence
>4eb7B (length=377) Species: 224325 (Archaeoglobus fulgidus DSM 4304) [Search protein sequence]
AYFDYTSAKPVDERILEAMLPYMTESFGNPSSVHSYGFKAREAVQEAREK
VAKLVNGGGGTVVFTSGATEANNLAIIGYAMRNARKGKHILVSAVEHMSV
INPAKFLQKQGFEVEYIPVGKYGEVDVSFIDQKLRDDTILVSVQHANNEI
GTIQPVEEISEVLAGKAALHIDATASVGQIEVDVEKIGADMLTISSNDIY
GPKGVGALWIRKEAKLQPVILGGGQENGLRSGSENVPSIVGFGKAAEITA
MEWREEAERLRRLRDRIIDNVLKIEESYLNGHPEKRLPNNVNVRFSYIEG
ESIVLSLDMAGIQASTGSACSSKTLQPSHVLMACGLKHEEAHGTLLLTLG
RYNTDEDVDRLLEVLPGVIERLRSMSP
3D structure
PDB4eb7 (IscS-IscU)2 complex structures provide insights into Fe2S2 biogenesis and transfer.
ChainB
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H98 D173 A176 D199 C321
Catalytic site (residue number reindexed from 1) H97 D172 A175 D198 C320
Enzyme Commision number 2.8.1.7: cysteine desulfurase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G233 S234 G232 S233
BS02 PLP B A69 T70 H98 N149 D173 T175 A68 T69 H97 N148 D172 T174
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0031071 cysteine desulfurase activity
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0016226 iron-sulfur cluster assembly
GO:0044571 [2Fe-2S] cluster assembly
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4eb7, PDBe:4eb7, PDBj:4eb7
PDBsum4eb7
PubMed22511353
UniProtO29689|ISCS2_ARCFU Cysteine desulfurase IscS 2 (Gene Name=iscS2)

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