Structure of PDB 4ea3 Chain B

Receptor sequence
>4ea3B (length=376) Species: 562,9606 [Search protein sequence]
LEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPKLEDKS
PDSPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYI
QKYLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFN
LALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLT
AMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAE
IECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLEKDRN
LRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTAL
GYVNSCLNPILYAFLDENFKACFRKF
3D structure
PDB4ea3 Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
ChainB
Resolution3.013 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0NN B Q107 D110 I127 D130 Y131 M134 C200 I219 S223 V283 T305 Y309 Q165 D168 I185 D188 Y189 M192 C253 I272 S276 V326 T348 Y352
Gene Ontology
Molecular Function
GO:0001626 nociceptin receptor activity
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0022900 electron transport chain
Cellular Component
GO:0016020 membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:4ea3, PDBe:4ea3, PDBj:4ea3
PDBsum4ea3
PubMed22596163
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P41146|OPRX_HUMAN Nociceptin receptor (Gene Name=OPRL1)

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