Structure of PDB 4e8g Chain B

Receptor sequence
>4e8gB (length=367) Species: 318586 (Paracoccus denitrificans PD1222) [Search protein sequence]
MKIAEIHVYAHDLPVKDGPYTISTVWSLQTTLVKIVADSGLAGWGETCPV
GPTYAPSHALGARAALAEMAPGLIGANPLQPLVLRRRMDGLLCGHNYAKA
AIDIAAYDLMGKHYGVRVADLLGGVAAERVPSYYATGIGQPDEIARIAAE
KVAEGFPRLQIKIGGRPVEIDIETVRKVWERIRGTGTRLAVDGNRSLPSR
DALRLSRECPEIPFVLEQPCNTLEEIAAIRGRVQHGIYLDESGEDLSTVI
RAAGQGLCDGFGMKLTRIGGLQQMAAFRDICEARALPHSCDDAWGGDIIA
AACTHIGATVQPRLNEGVWVAQPYIAQPYDEENGIRIAGGHIDLPKGPGL
GITPDESLFGPPVASFS
3D structure
PDB4e8g Prediction and biochemical demonstration of a catabolic pathway for the osmoprotectant proline betaine.
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y20 A137 Q162 K164 D194 N196 V217 E219 D242 E243 K266 D293 D294 A295 E318 G319 V320 W321
Catalytic site (residue number reindexed from 1) Y20 A135 Q160 K162 D192 N194 V215 E217 D240 E241 K264 D291 D292 A293 E316 G317 V318 W319
Enzyme Commision number 5.1.1.22: 4-hydroxyproline betaine 2-epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG B D194 E219 D242 D192 E217 D240
Gene Ontology
Molecular Function
GO:0016853 isomerase activity
GO:0016854 racemase and epimerase activity
GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives
GO:0036361 racemase activity, acting on amino acids and derivatives
GO:0046872 metal ion binding
Biological Process
GO:0006579 amino-acid betaine catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4e8g, PDBe:4e8g, PDBj:4e8g
PDBsum4e8g
PubMed24520058
UniProtA1B198|HPBD_PARDP 4-hydroxyproline betaine 2-epimerase (Gene Name=hpbD)

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