Structure of PDB 4e5u Chain B

Receptor sequence
>4e5uB (length=206) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
TGLFVTLEGPEGASTNRDYLAERLRERGIEVQLTREPGGTPLAERIRELL
LAPSDEPMAADTELLLMFAARAQHLAGVIRPALARGAVVLCDRFTDATYA
YQGGGRGLPEARIAALESFVQGDLRPDLTLVFDLPVEIGLARAAARGRLD
RFEQEDRRFFEAVRQTYLQRAAQAPERYQVLDAGLPLAEVQAGLDRLLPN
LLERLN
3D structure
PDB4e5u The crystal structure of thymidylate kinase from Pseudomonas aeruginosa PAO1 in complex with thymidine monophosphate.
ChainB
Resolution1.812 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.9: dTMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMP B E12 E39 M70 R74 R96 A100 T101 Y104 Q105 F155 E11 E36 M67 R71 R93 A97 T98 Y101 Q102 F152
BS02 CA B E12 E156 E11 E153
BS03 CA B A146 R149 A143 R146
Gene Ontology
Molecular Function
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0016310 phosphorylation
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4e5u, PDBe:4e5u, PDBj:4e5u
PDBsum4e5u
PubMed
UniProtQ9HZN8|KTHY_PSEAE Thymidylate kinase (Gene Name=tmk)

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