Structure of PDB 4e3x Chain B

Receptor sequence
>4e3xB (length=546) Species: 10090 (Mus musculus) [Search protein sequence]
GSHMLRWKHTSSLKVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCV
VGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWD
LKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELI
DFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGG
NLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGP
TFGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGG
KNFHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGR
LLEEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILA
GGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETL
KLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQ
QPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ
3D structure
PDB4e3x Proline: Mother Nature's cryoprotectant applied to protein crystallography.
ChainB
Resolution1.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N211 K233 E314 C348 E447 P532
Catalytic site (residue number reindexed from 1) N194 K216 E297 C331 E430 P515
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO B K292 A525 K275 A508
BS02 PRO B L302 D303 F305 T307 F308 L285 D286 F288 T290 F291
BS03 PRO B F210 D393 F193 D376
BS04 PRO B F212 C348 S349 G512 S513 F520 F195 C331 S332 G495 S496 F503
Gene Ontology
Molecular Function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006560 proline metabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4e3x, PDBe:4e3x, PDBj:4e3x
PDBsum4e3x
PubMed22868767
UniProtQ8CHT0|AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Gene Name=Aldh4a1)

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