Structure of PDB 4e2j Chain B

Receptor sequence

>4e2jB (length=247) Species: 32630 (synthetic construct) [Search protein sequence]

PTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWAK
ALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLVI
NEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKDG
LKSQAVFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEMV
GGLLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ

3D structure

PDB

4e2j Deciphering Modern Glucocorticoid Cross-pharmacology Using Ancestral Corticosteroid Receptors.

Chain

Resolution

2.5 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	V44 K48 R54 M62 Q66 E220 M221 E224 N228	V46 K50 R56 M64 Q68 E222 M223 E226 N230
BS02	MOF	B	M29 L32 N33 Q39 M70 M73 F92 M108 Q111 M115 F204 C205 T208	M31 L34 N35 Q41 M72 M75 F94 M110 Q113 M117 F206 C207 T210

External links

PDB	RCSB:4e2j, PDBe:4e2j, PDBj:4e2j
PDBsum	4e2j
PubMed	22437833

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