Structure of PDB 4e0s Chain B

Receptor sequence
>4e0sB (length=898) Species: 9606 (Homo sapiens) [Search protein sequence]
CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETR
ECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL
VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER
DCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV
KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHNENQQGVP
IFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDL
HLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFS
SEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGS
FIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAV
IDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRP
TLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYK
RSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKE
VDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQ
YFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTC
PKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLGHCQLGQKQSGSECIC
MSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGS
CQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPP
QCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
3D structure
PDB4e0s Crystal structure of c5b-6 suggests structural basis for priming assembly of the membrane attack complex.
ChainB
Resolution4.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B L135 N138 E140 D142 D148 E149 L135 N138 E140 D142 D148 E149
BS02 MAN B D4 W8 R25 D4 W8 R25
BS03 MAN B A495 D498 W550 R564 A484 D487 W539 R553
BS04 MAN B W547 E581 W536 E570
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006955 immune response
GO:0006956 complement activation
GO:0006958 complement activation, classical pathway
GO:0031640 killing of cells of another organism
GO:0045087 innate immune response
GO:0050778 positive regulation of immune response
Cellular Component
GO:0005576 extracellular region
GO:0005579 membrane attack complex
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4e0s, PDBe:4e0s, PDBj:4e0s
PDBsum4e0s
PubMed22500023
UniProtP13671|CO6_HUMAN Complement component C6 (Gene Name=C6)

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