Structure of PDB 4dvi Chain B

Receptor sequence
>4dviB (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]
QGTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKV
VNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAY
IGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLG
KSFLQFSTMKMAHAPPGHHSVIGRYAEYVIYRGEQAYPEYLITYQIMKPE
3D structure
PDB4dvi Novel binding mode of a potent and selective tankyrase inhibitor.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN B C1234 H1237 C1242 C1245 C127 H130 C135 C138
BS02 2IW B S1186 F1188 A1191 K1195 G1196 F1197 D1198 H1201 A1202 Y1203 G1211 I1212 Y1213 S83 F85 A88 K92 G93 F94 D95 H98 A99 Y100 G104 I105 Y106
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4dvi, PDBe:4dvi, PDBj:4dvi
PDBsum4dvi
PubMed22438990
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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