Structure of PDB 4dsh Chain B

Receptor sequence

>4dshB (length=465) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]

TPKIVIIGAGPTGLGAAVRLTELGYKNWHLYECNDTPGGLSRSFLDENGF
TWDLGGHVIFSHYQYFDDVMDWAVQGWNVLQRESWVWVRGRWVPYPFQNN
IHRLPEQDRKRCLDELVRSHARTYTEPPNNFEESFTRQFGEGIADIFMRP
YNFKVWAVPPCLMSTEWVEERVAPVDLERIRRNIQENRDDLGWGPNATFR
FPQRGGTGIIYQAIKEKLPSEKLTFNSGFQAIAIDADAKTITFSNGEVVS
YDYLISTVPFDNLLRMTKGTGFKGYDEWPAIADKMVYSSTNVIGIGVKGT
PPPHLKTACWLYFPEDTSPFYRATVFSNYSKYNVPEGHWSLMLEVSESKY
KPVNHSTLIEDCIVGCLASNLLLPEDLLVSKWHYRIEKGYPTPFIGRNNL
LEKAQPELMSRCIYSRGRFGAWRYEVGNQDHSFMQGVEAIDHVLGLATEE
TTVANPGRVNTHFGL

3D structure

PDB

4dsh Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation.

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

5.4.99.9: UDP-galactopyranose mutase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FDA	B	I12 G13 G15 P16 T17 E37 C38 G44 L45 S46 L59 G61 H62 V63 Q235 A236 V263 G422 R423 G432 N433 Q434 S437	I7 G8 G10 P11 T12 E32 C33 G39 L40 S41 L54 G56 H57 V58 Q230 A231 V258 G417 R418 G427 N428 Q429 S432
BS02	UDP	B	Y100 P101 F102 Q103 F152 M153 N157 R176 Y317 R327 Y395 Y429	Y95 P96 F97 Q98 F147 M148 N152 R171 Y312 R322 Y390 Y424

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity

View graph for
Molecular Function

External links

PDB	RCSB:4dsh, PDBe:4dsh, PDBj:4dsh
PDBsum	4dsh
PubMed	22646091
UniProt	Q4E1W2

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