Structure of PDB 4drx Chain B

Receptor sequence
>4drxB (length=424) Species: 9940 (Ovis aries) [Search protein sequence]
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVY
YNVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYT
EGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIRE
EYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEAL
YDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNM
VPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRH
GRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIP
PRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEME
FTEAESNMNDLVSEYQQYQDATAD
3D structure
PDB4drx A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end.
ChainB
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP B G10 Q11 C12 A99 G100 S140 G143 G144 T145 G146 E183 N206 Y224 N228 G10 Q11 C12 A90 G91 S131 G134 G135 T136 G137 E174 N197 Y215 N219
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Biological Process
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Cellular Component
External links
PDB RCSB:4drx, PDBe:4drx, PDBj:4drx
PDBsum4drx
PubMed22778434
UniProtD0VWY9

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