Structure of PDB 4drs Chain B

Receptor sequence
>4drsB (length=485) Species: 353152 (Cryptosporidium parvum Iowa II) [Search protein sequence]
KATCLGMDKITQRKTQIICTIGPSCNNVESLIGLIDKGMSVARLNFSHGD
HESHFKTLQNIREAAKARPHSTVGIMLDTKGPEIRTGMLEGGKPIELKAG
QTLKITTDYSMLGNSECISCSYSLLPKSVQIGSTVLIADGSLSTQVLEIG
DDFIVCKVLNSVTIGERKNMNLPGCKVHLPIIGDKDRHDIVDFALKYNLD
FIALSFVQNGADVQLCRQIISENTQYSNGIPSSIKIISKIENLEGVINFD
SICSESDGIMVARGDLGMEIPPEKIFVAQKCMISKCNVAGKPVVTATQML
ESMIKSNRPTRAEMTDVANAVLDGSDCVMLSGETANGAFPFDAVNVMSRV
CAQAETCIDYPVLYHAIHSSVPKPVAVPEAIACSAVESAHDVNAKLIITI
TETGNTARLISKYRPSQTIIACTAKPEVARGLKIARGVKTYVLNSIHHSE
VVISNALALAKEESLIESGDFAIAVHNLMKIVRCP
3D structure
PDB4drs Crystal structure of Cryptosporidium parvum pyruvate kinase.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R74 R116 K270 T328
Catalytic site (residue number reindexed from 1) R43 R85 K239 T297
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 SO4 B T432 T434 N436 T437 T401 T403 N405 T406
BS02 SO4 B K464 K470 K433 K439
BS03 GOL B R74 N76 R43 N45
BS04 GOL B N229 P457 E458 R461 N198 P426 E427 R430
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:4drs, PDBe:4drs, PDBj:4drs
PDBsum4drs
PubMed23056503
UniProtQ5CSM7

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