Structure of PDB 4dpu Chain B

Receptor sequence
>4dpuB (length=326) Species: 1282 (Staphylococcus epidermidis) [Search protein sequence]
VKSGKARAHTNIALIKYWGKADETYIIPMNNSLSVTLDRFYTETKVTFDP
DFTEDCLILNGNEVNAKEKEKIQNYMNIVRDLAGNRLHARIESENYVPTA
AGLASSASAYAALAAACNEALSLNLSDTDLSRLARRGSGSASRSIFGGFA
EWEKGHDDLTSYAHGINSNGWEKDLSMIFVVINNQSKKVSARSGMSLTRD
TSRFYQYWLDHVDEDLNEAKEAVKNQDFQRLGEVIEANGLRMHATNLGAQ
PPFTYLVQESYDAMAIVEQCRKANLPCYFTMDAGPNVKVLVEKKNKQAVM
EQFLKVFDESKIIASDIISSGVEIIK
3D structure
PDB4dpu Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.33: diphosphomevalonate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FM0 B A14 Y18 K21 S139 G140 S141 R144 A192 R193 M196 D283 A284 A13 Y17 K20 S138 G139 S140 R143 A191 R192 M195 D282 A283
BS02 AGS B L60 E69 S94 N96 A105 S106 S107 A110 L59 E68 S93 N95 A104 S105 S106 A109
Gene Ontology
Molecular Function
GO:0004163 diphosphomevalonate decarboxylase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008299 isoprenoid biosynthetic process
GO:0016310 phosphorylation
GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dpu, PDBe:4dpu, PDBj:4dpu
PDBsum4dpu
PubMed22734632
UniProtQ9FD73

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