Structure of PDB 4dm6 Chain B

Receptor sequence
>4dm6B (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
YEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDK
FSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRY
TPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETG
LLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKI
LMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLEN
3D structure
PDB4dm6 Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B K1246 I1260 P1410 L1411 Q1413 E1414 K67 I81 P231 L232 Q234 E235
BS02 TTB B F1230 L1233 A1234 C1237 L1271 I1272 I1275 F1288 S1289 F1304 G1393 V1397 L1400 I1412 F51 L54 A55 C58 L92 I93 I96 F109 S110 F125 G214 V218 L221 I233 BindingDB: EC50=4nM,Ki=0.500000nM,Kd=5nM,IC50=5nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4dm6, PDBe:4dm6, PDBj:4dm6
PDBsum4dm6
PubMed22355136
UniProtP10826|RARB_HUMAN Retinoic acid receptor beta (Gene Name=RARB)

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