Structure of PDB 4dld Chain B

Receptor sequence
>4dldB (length=254) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDV
KLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSK
PFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKIST
YEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCN
LTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG
NGCP
3D structure
PDB4dld Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZG B Y16 Y61 P88 L89 T90 R95 G140 S141 T142 S173 E190 S193 Y216 Y13 Y58 P85 L86 T87 R92 G137 S138 T139 S170 E187 S190 Y213 MOAD: Ki=1.5uM
BindingDB: Ki=3000nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4dld, PDBe:4dld, PDBj:4dld
PDBsum4dld
PubMed22407805
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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