Structure of PDB 4dk4 Chain B

Receptor sequence
>4dk4B (length=217) Species: 5691 (Trypanosoma brucei) [Search protein sequence]
LSPLILRSLAELQDGLNTVVDKNWRQLRRPGDWSLAITMEAAELLDSYPW
KWWKNVKAQPDLQNVKIELTDILHFSLSGAMQVDLADFMFFPLSDTNNAL
ASFQNIIRLASLQRFQLVTSAVIAAADDIGFNLVAYYVAKHTLNGIRQMK
GYKDGTYVKVQKGVEDNELLHGCISPFSLDDVTNEGNYKTKWDDIMHRVY
DAFGTPKEERLNIGHWL
3D structure
PDB4dk4 On the catalytic mechanism of dimeric dUTPases.
ChainB
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUN B K59 W60 W61 K51 W52 W53
BS02 DUN B N25 E48 D79 H82 F83 K208 N212 R215 Y220 K227 N17 E40 D71 H74 F75 K140 N144 R147 Y152 K159
BS03 CA B E48 E51 E40 E43
BS04 CA B E48 E51 E76 D79 E40 E43 E68 D71
Gene Ontology
Molecular Function
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4dk4, PDBe:4dk4, PDBj:4dk4
PDBsum4dk4
PubMed24001052
UniProtQ57ZH3

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