Structure of PDB 4dgg Chain B

Receptor sequence
>4dggB (length=259) Species: 9031 (Gallus gallus) [Search protein sequence]
AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPAFLQEA
QVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLP
QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLF
PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ
VERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTE
PQYQPGENL
3D structure
PDB4dgg Active site profiling reveals coupling between domains in SRC-family kinases.
ChainB
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D125 R127 A129 N130 D143 F150
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I76 B V281 A293 K295 M314 T338 Y340 M341 L393 F405 L407 V26 A38 K40 M53 T77 Y79 M80 L132 F144 L146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4dgg, PDBe:4dgg, PDBj:4dgg
PDBsum4dgg
PubMed23143416
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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