Structure of PDB 4dff Chain B

Receptor sequence
>4dffB (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
EIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYR
RVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGF
SNSYLSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIAT
DLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWP
VTKLTANDIYAEFWAEGDPIPMMDRKKDEVPQGQLGFYNAVAIPCYTTLT
QILPPTEPLLKACRDNLSQWEKVIRGE
3D structure
PDB4dff The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia.
ChainB
Resolution2.11 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0JP B F696 M713 Q726 F729 F213 M222 Q234 F237 MOAD: Ki=35nM
PDBbind-CN: -logKd/Ki=7.46,Ki=35nM
BindingDB: Ki=35nM
BS02 ZN B H529 H563 D564 D674 H59 H93 D94 D191
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:4dff, PDBe:4dff, PDBj:4dff
PDBsum4dff
PubMed22377514
UniProtQ9Y233|PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Gene Name=PDE10A)

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