Structure of PDB 4dd8 Chain B

Receptor sequence
>4dd8B (length=205) Species: 9606 (Homo sapiens) [Search protein sequence]
RETRYVELYVVVDNAEFQMLGSEAAVRHRVLEVVNHVDKLYQKLNFRVVL
VGLEIWNSQDRFHVSPDPSVTLENLLTWQARQRTRRHLHDNVQLITGVDF
TGTTVGFARVSAMCSHSSGAVNQDHSKNPVGVACTMAHEMGHNLGMDHDE
NVQGCRCQERFEAGRCIMAGSIGSSFPRMFSDCSQAYLESFLERPQSVCL
ANAPD
3D structure
PDB4dd8 Structure of human ADAM-8 catalytic domain complexed with batimastat.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BAT B T299 T300 V301 G302 H334 E335 H338 H344 G366 T103 T104 V105 G106 H138 E139 H142 H148 G170
BS02 CA B E203 D286 C395 N398 E7 D90 C199 N202
BS03 ZN B H334 H338 H344 H138 H142 H148
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4dd8, PDBe:4dd8, PDBj:4dd8
PDBsum4dd8
PubMed22684055
UniProtP78325|ADAM8_HUMAN Disintegrin and metalloproteinase domain-containing protein 8 (Gene Name=ADAM8)

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