Structure of PDB 4dc0 Chain B

Receptor sequence
>4dc0B (length=261) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
MATQDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKEL
REAGVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATA
ELADELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQG
VVHAAPYSASKHGVVGFTKALGLELARTGITVNAVCPGWVETPMAASVRE
HYSDIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQ
ALNVCGGLGNY
3D structure
PDB4dc0 The Determinants of Activity and Specificity in Actinorhodin Type II Polyketide Ketoreductase.
ChainB
Resolution2.813 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1) G17 N114 S144 Y157 K161 Y202
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B G13 T15 S16 I18 R38 G39 D63 V64 N90 A91 G92 A143 S144 Y157 K161 T192 P193 M194 G13 T15 S16 I18 R38 G39 D63 V64 N90 A91 G92 A143 S144 Y157 K161 T192 P193 M194
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4dc0, PDBe:4dc0, PDBj:4dc0
PDBsum4dc0
PubMed24035284
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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