Structure of PDB 4d7o Chain B

Receptor sequence
>4d7oB (length=410) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPRTKDQLFPLA
KEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHA
WRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSA
ITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQ
GWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLG
LKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILE
EVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESF
IKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQP
DPWNTHVWKG
3D structure
PDB4d7o Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus
ChainB
Resolution1.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C415 R418 W587 E592
Catalytic site (residue number reindexed from 1) C107 R110 W279 E284
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 H4B B W676 F691 E694 W368 F383 E386
BS02 HEM B W409 C415 F584 W587 E592 W678 F704 Y706 W101 C107 F276 W279 E284 W370 F396 Y398
BS03 H4B B S334 M336 R596 V677 W678 S36 M38 R288 V369 W370
BS04 0GD B M336 P565 V567 F584 W587 E592 Y706 M38 P257 V259 F276 W279 E284 Y398 MOAD: Ki=525nM
BS05 ZN B C326 C331 C28 C33
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:4d7o, PDBe:4d7o, PDBj:4d7o
PDBsum4d7o
PubMed26091171
UniProtP29476|NOS1_RAT Nitric oxide synthase 1 (Gene Name=Nos1)

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