Structure of PDB 4d11 Chain B

Receptor sequence

>4d11B (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]

KVRWPDFNQEAYVGGDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQW
RVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDP
EDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNE
HWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFK
WDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVW
GGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPGTVFARNTRRAAEVW
MDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELR
VPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEK
SVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQIEGNSKLRHVGSNL
CLDSRTAKSGGLSVEVCGPALSQQWKFTLNLQ

3D structure

PDB

4d11 Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N- Acetylgalactosaminyltransferase 2.

Chain

Resolution

2.85 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	A266 W282 F361 R362 K363 H365	A185 W201 F280 R281 K282 H284
BS02	peptide	B	F463 A464	F375 A376
BS03	MN	B	D224 H226 H359	D143 H145 H278
BS04	BBK	B	D458 L460 Y471 H474 N479	D370 L372 Y383 H386 N391
BS05	UDP	B	T143 F144 D176 R201 G203 L204 D224 S225 H226 H359 R362	T62 F63 D95 R120 G122 L123 D143 S144 H145 H278 R281

Gene Ontology

	Molecular Function
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515	protein binding
GO:0016757	glycosyltransferase activity
GO:0030145	manganese ion binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

	Biological Process
GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine
GO:0051604	protein maturation

	Cellular Component
GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4d11, PDBe:4d11, PDBj:4d11
PDBsum	4d11
PubMed	24954443
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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