Structure of PDB 4d0t Chain B

Receptor sequence

>4d0tB (length=495) Species: 9606 (Homo sapiens) [Search protein sequence]

KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHD
QCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILV
DDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLD
SHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGF
DWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKY
DMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSG
TVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCK
PFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECH
NAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCREDDSRQKWEQ
IEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLNL

3D structure

PDB

4d0t Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2.

Chain

Resolution

2.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	I252 I253 V255 A266 S267 L270 W282 W331 F361 K363	I178 I179 V181 A192 S193 L196 W208 W257 F287 K289
BS02	MN	B	D224 H226 H359	D150 H152 H285
BS03	UD2	B	T143 F144 D176 R201 L204 D224 S225 H226 A307 G308 G309 W331 G332 E334 H359 R362 Y367	T69 F70 D102 R127 L130 D150 S151 H152 A233 G234 G235 W257 G258 E260 H285 R288 Y293

Gene Ontology

	Molecular Function
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515	protein binding
GO:0016757	glycosyltransferase activity
GO:0030145	manganese ion binding
GO:0030246	carbohydrate binding
GO:0046872	metal ion binding

	Biological Process
GO:0006486	protein glycosylation
GO:0006493	protein O-linked glycosylation
GO:0016266	O-glycan processing
GO:0018242	protein O-linked glycosylation via serine
GO:0018243	protein O-linked glycosylation via threonine
GO:0051604	protein maturation

	Cellular Component
GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005795	Golgi stack
GO:0016020	membrane
GO:0032580	Golgi cisterna membrane
GO:0048471	perinuclear region of cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:4d0t, PDBe:4d0t, PDBj:4d0t
PDBsum	4d0t
PubMed	24954443
UniProt	Q10471\|GALT2_HUMAN Polypeptide N-acetylgalactosaminyltransferase 2 (Gene Name=GALNT2)

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