Structure of PDB 4cxm Chain B

Receptor sequence
>4cxmB (length=280) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
KKWFSEFSIMWPGQAFSLKIKKILYETKSKYQNVLVFESTTYGKVLVLDG
VIQLTEKDEFAYHEMMTHVPMTVSKEPKNVLVVGGGDGGIIRELCKYKSV
ENIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDASKFLENVTNTY
DVIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTI
KNMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLES
KEFADLKYYNYENHSAAFKLPAFLLKEIEN
3D structure
PDB4cxm Three-Dimensional Structures of Plasmodium Falciparum Spermidine Synthase with Bound Inhibitors Suggest New Strategies for Drug Design.
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MTA B G124 G125 D127 E147 I148 V152 D178 A179 D196 S198 P203 A204 L207 G84 G85 D87 E107 I108 V112 D138 A139 D156 S158 P163 A164 L167
BS02 SPD B V91 Q93 Y102 H103 D127 D196 S197 D199 Y264 V51 Q53 Y62 H63 D87 D156 S157 D159 Y224
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:4cxm, PDBe:4cxm, PDBj:4cxm
PDBsum4cxm
PubMed25760598
UniProtQ8II73

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