Structure of PDB 4crx Chain B

Receptor sequence

>4crxB (length=322) Species: 10678 (Punavirus P1) [Search protein sequence]

SDEVRKNLMDMFRDRQAFSEHTWKMLLSVCRSWAAWCKLNNRKWFPAEPE
DVRDYLLYLQARGLAVKTIQQHLGQLNMLHRRSGLPRPSDSNAVSLVMRR
IRKENVDAGERAKQALAFERTDFDQVRSLMENSDRCQDIRNLAFLGIAYN
TLLKIAEIARIRVKDISRTDGGRMLIHIGRTKTLVSTAGVEKALSLGVTK
LVERWISVSGVADDPNNYLFCRVRKNGVAAPSATSQLSTRALEGIFEATH
RLIYGAKDDSGQRYLAWSGHSARVGAARDMARAGVSIPEIMQAGGWTNVN
IVMNYIRNLDSETGAMVRLLED

3D structure

PDB

4crx Asymmetric DNA bending in the Cre-loxP site-specific recombination synapse.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	M44 S47 R50 R81 L83 A84 K86 T87 R118 K122 A131 K132 R159 K173 K201 R241 V242 K244 L256 S257 R259 R282 R292 W315 T316 I320	M25 S28 R31 R62 L64 A65 K67 T68 R99 K103 A112 K113 R140 K154 K182 R222 V223 K225 L237 S238 R240 R263 R273 W296 T297 I301
BS02	dna	B	S38 H40 T41 M97 R100 R101 R106 R121 A175 K201 R243 K244 R259 E262 K276 R282 Y283 S287 G288 H289	S19 H21 T22 M78 R81 R82 R87 R102 A156 K182 R224 K225 R240 E243 K257 R263 Y264 S268 G269 H270

Gene Ontology

	Molecular Function
GO:0003677	DNA binding

	Biological Process
GO:0006310	DNA recombination
GO:0015074	DNA integration

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4crx, PDBe:4crx, PDBj:4crx
PDBsum	4crx
PubMed	10377382
UniProt	P06956\|RECR_BPP1 Recombinase cre (Gene Name=cre)

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