Structure of PDB 4cn7 Chain B

Receptor sequence

>4cn7B (length=79) Species: 9606 (Homo sapiens)

KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK
RQRNRCQYCRYQKCLAMGMKREAVQEERQ

3D structure

• PDB: 4cn7 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
• Chain: B
• Resolution: 2.34 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	B	K145 H146 Y147 K156 K160 R164 V205 Q206 E208 R209	K14 H15 Y16 K25 K29 R33 V74 Q75 E77 R78	PDBbind-CN: Kd=155nM
BS02	dna	B	E153 G154 F158 R161 K165 R184 N185 Q188 R191 R209	E22 G23 F27 R30 K34 R53 N54 Q57 R60 R78	PDBbind-CN: Kd=155nM
BS03	dna	B	Y169 Q188	Y38 Q57	PDBbind-CN: Kd=155nM
BS04	ZN	B	C135 C138 C152 C155	C4 C7 C21 C24
BS05	ZN	B	C171 C177 C187 C190	C40 C46 C56 C59

Gene Ontology

Molecular Function

• GO:0003700 DNA-binding transcription factor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:4cn7, PDBe:4cn7, PDBj:4cn7
• PDBsum: 4cn7
• PubMed: 25645674
• UniProt: P19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)