Structure of PDB 4cn3 Chain B

Receptor sequence
>4cn3B (length=76) Species: 9606 (Homo sapiens) [Search protein sequence]
HICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKR
QRNRCQYCRYQKCLAMGMKREAVQEE
3D structure
PDB4cn3 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
ChainB
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H146 Y147 K160 R164 A204 Q206 H14 Y15 K28 R32 A72 Q74 PDBbind-CN: Kd=44nM
BS02 dna B E153 G154 F158 R161 R184 N185 R191 E21 G22 F26 R29 R52 N53 R59 PDBbind-CN: Kd=44nM
BS03 ZN B C135 C138 C152 C155 C3 C6 C20 C23
BS04 ZN B C171 C177 C187 C190 C39 C45 C55 C58
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn3, PDBe:4cn3, PDBj:4cn3
PDBsum4cn3
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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