Structure of PDB 4cmx Chain B

Receptor sequence
>4cmxB (length=291) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
VSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDYQQ
AALRQSIRILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLAN
DEEILSFYKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTE
HRLCFGVFGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADM
FIGFGRFSTFDFPLLSSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHF
RPKPDYSAMSADQLNVLRNRYRADRVFGVGCVHDGIWFAEG
3D structure
PDB4cmx Molecular Profiling of Mycobacterium Tuberculosis Identifies Tuberculosinyl Nucleoside Products of the Virulence-Associated Enzyme Rv3378C.
ChainB
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D34 R38 Y51 Y90
Catalytic site (residue number reindexed from 1) D31 R35 Y48 Y87
Enzyme Commision number 2.5.1.153: adenosine tuberculosinyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BHC B K256 P257 Y259 K253 P254 Y256
BS02 BHC B R37 R38 D85 R86 R89 R34 R35 D82 R83 R86
Gene Ontology
Molecular Function
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0016791 phosphatase activity
GO:0062204 (13S)-vitexifolin A synthase activity
Biological Process
GO:0016102 diterpenoid biosynthetic process
GO:0035440 tuberculosinol biosynthetic process
GO:0052572 response to host immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:4cmx, PDBe:4cmx, PDBj:4cmx
PDBsum4cmx
PubMed24516143
UniProtP9WJ61|TUBAT_MYCTU Tuberculosinyl adenosine transferase (Gene Name=Rv3378c)

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