Structure of PDB 4cjx Chain B

Receptor sequence
>4cjxB (length=297) [Search protein sequence]
MPEAVVIDGRAVAKAIQKELTEEVALLERRYKGRRPGLSTIICGKRKDSQ
TYVRLKRKAAAACGFRNFSVELPANVTQEALEREVIRLNEEEACHSIVVQ
LPLPPHIDKVAALSKIKPEKDADCLLPVNVGQLHIRERNPAIVPCTASAV
MELLRCSGVEICGKRVVVLGRGDIAGLPVATLLANEDATVTVVHSATPLC
DIADIVRASDIVVSAAGQPGLVRGEWIKLGAAVIDVGTTPVADPSKVPGY
RLVGDVCFDVARKRAAYITPVPGGVGPVTVSMLLKNTLTMFKRSVRA
3D structure
PDB4cjx Characterization of 2,4-Diamino-6-Oxo-1,6-Dihydropyrimidin-5-Yl Ureido Based Inhibitors of Trypanosoma Brucei Fold and Testing for Antiparasitic Activity.
ChainB
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.5: methylenetetrahydrofolate dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9L9 B Y52 K56 V99 Q100 L101 D123 I174 L252 P272 G273 G276 P277 Y52 K56 V99 Q100 L101 D123 I174 L252 P272 G273 G276 P277
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004477 methenyltetrahydrofolate cyclohydrolase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0016491 oxidoreductase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol
GO:0020023 kinetoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cjx, PDBe:4cjx, PDBj:4cjx
PDBsum4cjx
PubMed26322631
UniProtQ57WP0

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