Structure of PDB 4ci2 Chain B

Receptor sequence
>4ci2B (length=370) Species: 9031 (Gallus gallus) [Search protein sequence]
MINFDTSLPTSHMYLGSDMEEFHGRTLHDDDSCQVIPVLPHVMVMLIPGQ
TLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVREREAHFGTTAEIYAYR
EEQEYGIETVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPERVLPSTMS
AVQLQSLSRRHIRAFRQWWQKYQKRKFHCASLTSWPPWLYSLYDAETLME
RVKRQLHEWDENLKDESLPTNPIDFSYRVAACLPIDDALRIQLLKIGSAI
QRLRCELDIMNKCTSLCCKQCQDTEITTKNEIFSLSLCGPMAAYVNPHGY
IHETLTVYKACNLNLSGRPSTEHSWFPGYAWTIAQCRICGNHMGWKFTAT
KKDMSPQKFWGLTRSALLPR
3D structure
PDB4ci2 Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide.
ChainB
Resolution2.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C325 C328 C393 C396 C268 C271 C336 C339
BS02 LVY B N353 P354 H355 H380 S381 W382 W388 W402 F404 N296 P297 H298 H323 S324 W325 W331 W345 F347 PDBbind-CN: -logKd/Ki=6.75,Kd=177.8nM
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ci2, PDBe:4ci2, PDBj:4ci2
PDBsum4ci2
PubMed25043012
UniProtP0CF65|CRBN_CHICK Protein cereblon (Gene Name=CRBN)

[Back to BioLiP]