Structure of PDB 4cdg Chain B

Receptor sequence
>4cdgB (length=616) Species: 9606 (Homo sapiens) [Search protein sequence]
HERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMP
TGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLTGD
KTDSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLA
RFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKD
ILTQLKILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDS
GIIYCLSRRECDTMADTLQRDGLAALAYHAGLSDSARDEVQQKWINQDGC
QVICATIAFGMGIDKPDVRFVIHASLPKSVEGYYQESGRAGRDGEISHCL
LFYTYHDVTRLKRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPD
FCKKHPDVSCDNCCKTKDYKTRDVTDDVKSIVRFVQEHSGRFTMNMLVDI
FLGSKSAKIQSGIFGKGSAYSRHNAERLFKKLILDKILDEDLYINQAIAY
VMLGNKAQTVLNGNLKVDFMETENSSSVKKQKAVSQREEMVKKCLGELTE
VCKSLGKVFGVHYFNIFNTVTLKKLAESLSSDPEVLLQIDGVTEDKLEKY
GAEVISVLQKYSEWTS
3D structure
PDB4cdg Crystal Structure of the Bloom'S Syndrome Helicase Indicates a Role for the Hrdc Domain in Conformational Changes.
ChainB
Resolution2.794 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B L665 N667 R669 Q672 G692 G694 K695 S696 R982 L25 N27 R29 Q32 G52 G54 K55 S56 R342
BS02 ZN B C1036 C1055 C1066 C383 C402 C413
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0043138 3'-5' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4cdg, PDBe:4cdg, PDBj:4cdg
PDBsum4cdg
PubMed25901030
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

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