Structure of PDB 4ccn Chain B

Receptor sequence
>4ccnB (length=459) Species: 9606 (Homo sapiens) [Search protein sequence]
MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLCSPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRAPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
AGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE
PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGL
LLTKMPLAL
3D structure
PDB4ccn Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
ChainB
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q260 R272 T274 R297 C299 S300 M322 N326 Y328 H340 D342 N376 S421 Q424 Q79 R91 T93 R116 C118 S119 M141 N145 Y147 H159 D161 N195 S240 Q243
BS02 MN B H340 D342 H405 H159 D161 H224
External links
PDB RCSB:4ccn, PDBe:4ccn, PDBj:4ccn
PDBsum4ccn
PubMed24814345
UniProtQ9H6W3|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)

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