Structure of PDB 4ccm Chain B

Receptor sequence
>4ccmB (length=459) Species: 9606 (Homo sapiens) [Search protein sequence]
MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRRLWEREAVLVR
RQDHTYYQGLFSTADLDSMLRNEEVQFGQHLDAARYINGRRETLNPPGRA
LPAAAWSLYQAGCSLRLLCPQAFSTTVWQFLAVLQEQFGSMAGSNVYLTP
PNSQGFAPHYDDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDD
LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLSTYQRNTWGDF
LEAILPLAVQAAMEENVEFRRGLPRDFMDYMGAQHSDSKDPRRTAFMEKV
RVLVARLGHFAPVDAVADQRAKDFIHDSLPPVLTDRERALSVYGLPIRWE
AGEPVNVGAQLTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE
PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSLATTLYDKGL
LLTKMPLAL
3D structure
PDB4ccm Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
ChainB
Resolution2.51 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.27: [histone H3]-dimethyl-L-lysine(36) demethylase.
1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Q260 R272 T274 R297 L299 C300 M322 N326 Y328 H340 D342 N376 S421 Q424 Y577 Q79 R91 T93 R116 L118 C119 M141 N145 Y147 H159 D161 N195 S240 Q243 Y396
BS02 MN B H340 D342 H405 H159 D161 H224
External links
PDB RCSB:4ccm, PDBe:4ccm, PDBj:4ccm
PDBsum4ccm
PubMed24814345
UniProtQ9H6W3|RIOX1_HUMAN Ribosomal oxygenase 1 (Gene Name=RIOX1)

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