Structure of PDB 4c9z Chain B

Receptor sequence
>4c9zB (length=188) Species: 9606 (Homo sapiens) [Search protein sequence]
LFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAV
MPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLE
KQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIH
EGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4c9z Two High-Resolution Structures of the Human E3 Ubiquitin Ligase Siah1.
ChainB
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C128 C135 H147 H152 C34 C41 H53 H58
BS02 ZN B C98 H117 C121 C4 H23 C27
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4c9z, PDBe:4c9z, PDBj:4c9z
PDBsum4c9z
PubMed24316825
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

[Back to BioLiP]