Structure of PDB 4c8e Chain B

Receptor sequence
>4c8eB (length=161) Species: 216591 (Burkholderia cenocepacia J2315) [Search protein sequence]
MDVRIGQGYDVHQLVEGRPLIIGGVTIPYERGLLGHSDADVLLHAITDAL
FGAAALGDIGRHFSDTDAAFKGADSRVLLRACAERVKAAGFTIQNVDSTV
IAQAPKLAPHIDGMRANIAADLGLPLERVNVKAKTNEKLGYLGRGEGIEA
QAAALLVKQGG
3D structure
PDB4c8e Crystal Structures of Ispf from Plasmodium Falciparum and Burkholderia Cenocepacia: Comparisons Inform Antimicrobial Drug Target Assessment.
ChainB
Resolution1.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.6.1.12: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D10 H12 H44 D10 H12 H44
BS02 C5P B A102 L107 A108 A133 K134 T135 A102 L107 A108 A133 K134 T135
BS03 C5P B D10 H12 H36 H44 I59 D65 L78 D10 H12 H36 H44 I59 D65 L78
BS04 C5P B D58 G60 D58 G60
Gene Ontology
Molecular Function
GO:0008685 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0016114 terpenoid biosynthetic process
GO:0019288 isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4c8e, PDBe:4c8e, PDBj:4c8e
PDBsum4c8e
PubMed24410837
UniProtB4EC22|ISPF_BURCJ 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (Gene Name=ispF)

[Back to BioLiP]